Using light to treat human diseases is a very old method. As early as thousands of years ago, China and other countries used sunlight to treat diseases. As a new type of light source, LED is gradually being applied in medicine and plays an active role as its biological effects are gradually recognized by people, this article will explain and describe the application of LED in skin medicine in detail. I. Optical parameters that affect the biological effect of LED the biological effect of LED depends on different optical parameters, including different wavelengths, flow rates, intensities, Irradiation time, continuous wave or pulse wave, clinical treatment times, treatment intervals, etc. Different wavelengths can reach different positions of skin tissue (Figure 1). Generally speaking, the longer the wavelength, the stronger the penetration ability. The distance of skin tissue penetrating at 400nm is no more than 1mm, and the distance penetrating at 514nm is about 0. 5mm ~ 2mm, 630nm penetration distance of about 1mm ~ 6mm. At the same time, light of different wavelengths can be absorbed by different color groups in the tissue. Clinically red light (630nm ~ 700nm) It is often used to treat deep skin tissue structures, such as sebaceous glands; Blue light is used to treat skin lesions located in epidermis in photodynamic therapy; If you want to reach the dermis layer of the skin, you need a longer wavelength, for example, the wavelength of 660nm can reach the reticular layer of the dermis, thus playing a role in the skin fibroblasts in the dermis, this is also one of the principles of LED light source for photon rejuvenation. II. application of led in dermatology 1. Photon rejuvenation ( photorejuvenation) Photon skin rejuvenation technology is defined as non-exfoliation skin rejuvenation treatment using continuous intense pulsed light at low energy density. In just a few years since its inception in 2000, photon skin rejuvenation technology has been rapidly popularized throughout the country and widely used in large and medium-sized cities. At present, it has become one of the main means to improve skin photoaging, this technology can obviously improve skin wrinkles, rough texture, irregular pigmentation and enlarged pores, and has been recognized by many technical professionals and beauty appeals. The characteristic histological change of skin photoaging is elastic fibrosis and collagen fiber maturation disorder in dermal matrix, which leads to relaxation and wrinkles of skin. Studies have found that after LED light from visible light to near infrared penetrates the skin epidermis to reach the skin dermis layer, elastic fibers and collagen fibers are regenerated and rearranged through photothermal and photochemical effects, thereby achieving the effect of reducing skin wrinkles and increasing elasticity. 2. Prevention or treatment of pigmentation after inflammation pigmentation of skin after inflammation is a common and difficult phenomenon to avoid in skin physical and chemical beauty, especially easy to appear in Asian people. For example, in order to reduce the degree of skin pigmentation after laser treatment, patients are generally advised to avoid the season when ultraviolet rays are too strong, to avoid sunlight, to apply sunscreen, etc. , but pigmentation after inflammation is still difficult to completely avoid. In recent years, studies have found that 660nm LED light can prevent or even treat skin pigmentation after this inflammation, which will be a new research hotspot in the field of skin beauty. 3. To promote wound healing, it can be seen that LED light of various bands in near infrared can promote the growth of epithelial cells after trauma and promote wound healing. At the same time, it also has a good therapeutic effect on the healing of chronic ulcer of lower limbs of diabetic patients. 4. To reduce inflammation, a series of studies have shown that LED has anti-inflammatory effects. Studies have found that 635nm LED light can inhibit gingival fibroblasts from releasing inflammatory mediator prostatic cycline E2 (PGE2)So as to reduce the inflammatory reaction of gums. If LED light source is used to irradiate in advance before pulsed dye laser is used to treat skin photoaging, discomfort such as skin erythema, swelling and pain caused by dye laser can be relieved. Early irradiation with LED light source before radiotherapy for breast cancer patients can reduce the side effects of radiotherapy. 5. Scar Prevention keloid is a skin disease that affects beauty and is difficult to treat clinically. It is caused by excessive proliferation of connective tissue after skin injury. Patients often have scar constitution. Clinically, it begins to be a small and hard red papule, which slowly increases, producing round, oval or irregular scars, which are higher than the skin surface, stretching outward in the shape of crab feet, and the skin is smooth and shiny, may be accompanied by pain, itching and other discomfort. Clinical treatment is difficult and the curative effect is not ideal. Some studies have found that LED can obviously improve patients' discomfort such as pain and pruritus, flatten scars, and has the advantages of non-invasive. 6. Other functions, in addition, LED can also be used as a phototherapy instrument without ultraviolet rays, used for photodynamic therapy, treatment of alopecia, reduction of skin damage after ultraviolet irradiation, etc. In a word, as a new type of light source, LED has been gradually applied to dermatology. With the continuous innovation of LED lamps and the mechanism research of LED biological effects in medicine, the application of LED in dermatology will have unlimited prospects. At the same time, LED has high safety and can be used as a home medical equipment.